Deacetyllanatoside C

Deacetyllanatoside C - General Information

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata. [PubChem]

Pharmacology of Deacetyllanatoside C

Deacetyllanatoside C is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

Additional information about Deacetyllanatoside C

Deacetyllanatoside C Indication: For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.
Mechanism Of Action: Deacetyllanatoside C inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Deacetyllanatoside C also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Deslanoside
Synonyms: Not Available
Drug Category: Anti-Arrhythmia Agents; Cardiotonic Agents; Enzyme Inhibitors
Drug Type: Small Molecule; Approved

Other Brand Names containing Deslanoside: Cedilanid-d; Deacetyllanatoside C;
Absorption: Little absorption from the gastrointestinal tract (40%).
Toxicity (Overdose): Symptoms of overdose include ventricular tachycardia, ventricular fibrillation, progressive bradyarrhythmias, or heart block.
Protein Binding: 20%
Biotransformation: Not Available
Half Life: 36 hours
Dosage Forms of Deacetyllanatoside C: Not Available
Chemical IUPAC Name: 4-[(3S,5R,8R,9R,10S,12R,13S,14S,17R)-12,14-dihydroxy-3-[(2R,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Chemical Formula: C47H74O19
Deslanoside on Wikipedia: https://en.wikipedia.org/wiki/Deslanoside
Organisms Affected: Humans and other mammals